Two young men, Singh and Yai were hunting a wolf that  bit Duen, Singh's wife who was pregnant. Taa Yoi and his little master, Anirut stayed in an abandoned building. Anirut was an offspring of the last wolf in the world.  Frank a digging man and his niece, Lilly always ran away from Dang and Dam's gangster to hide safely in the building. As usual, tonight Frank and Lilly came to hide there, but unfortunately, it was a full moon! With curiosity, Lilly walked around the building and got lost into Anirut's cage. Frank tried to protect his niece from Anirut's claw, so he was bitten at the neck.

Tonight with a crescent moon, Frank became a wolf, not alike a wolf in the legend but a leprous wolf. At the same time, Dang and Dam tried to rape Chu-chi. Coincidently, Frank saw the event and rescued Chu-chi. Singh, Yai and the Digging gang met Taa Yoi and Anirut when Anirut escaped and Chu-chi took Frank to see Taa Yoi for a cure. They wanted the wolf's heart for Duen to eat so they followed Frank.

KhunDej transformed into a wolf and hunted Anirut whereas Singh nad Yai hunted Frank, a leprous wolf closely. Accidentally, Anirut and frank had a crashed and merged into a huge colossal wolf and fight with KhunDej. Singh and Yai remembered KhunDej the wanted wolf. There was a savage fight between two wolves. KhunDej was defeated. Singh got KhunDej's heart for Deun. Frank and Anirut turned to be a man, but who could help them? They were still the werewolves!